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Parkemed 500 mg film-coated tablets

Prescription required:Yes
Active ingredient:Mefenamic acid 500 mg
Application:Other (monopreparations)

How does the remedy work?

The active ingredient mefenamic acid belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs). It inhibits the formation of prostaglandins (messenger substances) and thus has an analgesic, anti-inflammatory and fever-lowering effect. Mefenamic acid is broken down in the liver and excreted in the urine and stool.

In which areas of application is the product used?

Acute and chronic pain

how do you apply the product?

Parkemed film-coated tablets should whole with liquid be taken with meals.

  • Adults and adolescents from the age of 14 take 500 mg to 1500 mg (1–3 tablets), divided into several daily doses, depending on the severity of the disease.
  • 250 mg capsules are available for children from 10 years of age and for adolescents from 12 to 14 years of age, other dosage forms are available for younger children.
  • When treating menstrual pain, Parkemed should be taken with the onset of pain.

When should the product not be used?

  • Hypersensitivity to the active substance or one of the auxiliary substances
  • in patients who have shown asthma or other allergic reactions after taking acetylsalicylic acid (Aspirin, Aspro, ..) or other similarly effective painkillers (such as: Voltaren, Seractil, Novalgin, Mexalen)
  • in patients with bleeding tendencies and haemorrhage disorders
  • in patients with active or healed ulcers or chronic inflammation of the gastrointestinal tract
  • in patients with kidney disease and impaired kidney function
  • in patients with heart failure and liver dysfunction
  • in the treatment of post-operative pain
  • after coronary bypass surgery

Can the product be used by pregnant and breastfeeding women?

Parkemed should only be taken during the first and second trimesters of pregnancy if absolutely necessary. Parkemed should not be used during the third trimester of pregnancy and breastfeeding.

Which side effects can occur?

Often: Side effects related to the gastrointestinal tract such as diarrhea, vomiting, gas, abdominal pain, etc. and an increased number of eosinophils (a type of white blood cell). If diarrhea persists, the dose should be reduced or treatment should be discontinued.


  • sleepiness
  • fatigue
  • dizziness
  • Hypersensitivity reactions of the skin and respiratory tract
  • Kidney dysfunction
  • Visual disturbances
  • tinnitus
  • Palpitations
  • nervousness
  • depression
  • Liver and gallbladder diseases such as jaundice and hepatitis

Interactions are known with the following substances:

  • Anticoagulants
  • Corticoids
  • Methotrexate
  • lithium
  • Antidiabetic drugs
  • Diuretics
  • Cyclosporine
  • Tacrolimus
  • Quinolones

Warning notices

  • Long-term treatment with Parkemed can lead to spontaneous bleeding, ulcers or perforations in the gastrointestinal tract.
  • The function of the liver and kidneys can be impaired, so the blood count and kidney function should be checked regularly, especially in the case of long-term therapy.
  • Treatment can also increase the risk of heart attack and stroke.
  • High blood pressure, edema, and fluid build-up in the body are also possible.
  • Treatment should be discontinued if there are signs of liver dysfunction, abnormal liver parameters or rashes appear.

Note: The list of drugs in no way represents a recommendation, sales promotion or advertising of the individual drugs in any way.

The information is by no means conclusive and is not a substitute for medical or other specialist advice.

The attending physician or pharmacist should be consulted, particularly with regard to side effects, contraindications and other information.

Status of information: July 2019