How can a Neurobion tablet be used

Neurobion® N forte - package insert

1 What is Neurobion® N forte and what is it used for?

Neurobion® N forte is a vitamin B1 + B6 preparation against neurological diseases. It can be used for systemic neurological diseases due to a proven deficiency of vitamins B1 and B6.

2 What should you watch out for before taking Neurobion® N forte?

Neurobion® N forte must not be taken

  • if you are hypersensitive (allergic) to one of the active ingredients or one of the other ingredients of Neurobion® N forte.

Take special care when taking Neurobion® N forte:

Vitamin B6 in daily doses of 50 mg or more can cause neuropathies over a long period of time (months to years). If signs of peripheral sensory neuropathy occur (abnormal sensations predominantly in the hands and feet), the attending physician should be consulted.

This medicine contains sucrose (sugar) and lactose. Therefore, please only take Neurobion® N forte after consulting your doctor if you know that you suffer from an intolerance to certain sugars.

Taking Neurobion® N forte with other drugs:

Therapeutic doses of vitamin B6 can weaken the effects of the anti-Parkinsonian drug LDopa.

The simultaneous administration of so-called pyridoxine antagonists (drugs that, among other things, have an effect against vitamin B6, such as hydralazine, isoniazid (INH), cycloserine, D-penicillamine) can increase the need for vitamin B6.

Neurobion® N forte loses its effect if the anti-cancer drug (cytostatic) 5-fluorouracil is administered at the same time.

Stomach acid inhibitors reduce the absorption of vitamin B1.

Long-term treatment with the dehydrating agent furosemide can lead to a vitamin B1 deficiency because more vitamin B1 is excreted in the urine.

Please note that this information can also apply to recently used drugs.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Taking Neurobion® N forte with food and drink:

Alcohol and black tea reduce the absorption of vitamin B1.

Vitamin B1 can be broken down and thus become ineffective when drinks containing sulphites, such as wine, are consumed at the same time.

Pregnancy and breast feeding period:

Ask your doctor or pharmacist for advice before taking any medicine.

During pregnancy and breastfeeding, the recommended daily intake for vitamin B1 is 1.4-1.6 mg and for vitamin B6 2.4-2.6 mg. These doses may only be exceeded during pregnancy if the patient has a proven vitamin B1 and B6 deficiency.

Systematic studies on the use of vitamins B1 and B6 are not available. The use of this preparation during pregnancy and breastfeeding should therefore only be decided by the attending physician after careful risk / benefit assessment. High doses of vitamin B6 can inhibit milk production. Vitamin B1 and vitamin B6 pass into breast milk.

Driving and using machines:

There are no special precautions required.

Important information about certain other ingredients of Neurobion® N forte:

This medicine contains sucrose (sugar) and lactose. Therefore, please only take Neurobion® N forte after consulting your doctor if you know that you suffer from an intolerance to certain sugars.

3 How should Neurobion® N forte be taken?

Always take Neurobion® N forte exactly as instructed in this package insert. Please ask your doctor or pharmacist if you are not sure.

Unless otherwise prescribed, adults take one coated tablet of Neurobion® N forte once a day. If the deficiency is manifestly proven, the dose can be increased to one coated tablet up to 3 times a day after consulting the attending physician.

How and when should you take Neurobion® N forte?

The coated tablets are swallowed whole with sufficient liquid (e.g. 1 glass of water) with or after meals.

How long should you take Neurobion® N forte?

After 4 weeks at the latest, the attending physician should decide whether the administration of vitamin B6 and vitamin B1 in the high concentration present here is still indicated. If necessary, you should switch to a preparation with a lower active ingredient strength in order to reduce the risk of neuropathy associated with vitamin B6.

If you take more Neurobion® N forte than you should:

Long-term ingestion (months to years) of vitamin B6 in doses over 50 mg / day and short-term ingestion (2 months) in doses over 1g / day can lead to neurotoxic effects (see warnings).

Overdosing is mainly indicated by sensory polyneuropathy, possibly with ataxia. Extremely high doses can manifest as cramps.

When acutely doses above 150 mg / kg

Body weight, artificially induced vomiting and the administration of activated charcoal are recommended. Vomiting is most effective in the first 30 minutes after ingestion. Intensive medical measures may be required.

High doses of vitamin B6 can inhibit milk production during breastfeeding. If you experience physical symptoms, you should consult a doctor.

If you forget to take Neurobion® N forte:

Do not take a double dose to make up for a forgotten dose. Continue taking as described in the dosage instructions.

If you stop taking Neurobion® N forte:

For a successful treatment it is important that you take Neurobion® N forte for the entire length of time recommended by your doctor.

If you have any further questions on the use of the medicinal product, please ask your doctor or pharmacist.

4 What side effects are possible?

Like all medicinal products, Neurobion® N forte can have side effects, but these do not necessarily affect everyone.

Significant side effects or signs to look out for and what to do if they're affected:

If you are affected by one of the side effects listed below, stop taking Neurobion® N forte and contact your doctor as soon as possible.

Very rarely, after oral administration of thiamine (vitamin B1), hypersensitivity reactions (sweating, racing heart (tachycardia), skin reactions with itching and wheals (urticaria)) can occur.

When evaluating side effects, the following frequencies are used as a basis:

very often:More than 1 in 10 people treated
often:More than 1 in 100 people treated
occasionally:More than 1 in 1000 people treated
Rare:More than 1 in 10,000 people treated
very rare:1 or less in 10,000 people treated, including individual cases

Other possible side effects

Long-term overdosing of vitamin B6 (longer than 2 months in an ingestion of more than 1g / day) can cause nerve-damaging effects. Long-term ingestion (more than 6 - 12 months) of daily amounts of more than 50 mg vitamin B6 can cause peripheral sensory neuropathy (abnormal sensations mainly in the hands and feet) (see precautionary measures for intake and warnings).

What countermeasures need to be taken, if any?

If you experience side effects, stop taking Neurobion® N forte and contact your doctor.

If you get any side effects, talk to your doctor, pharmacist or nurse. This also applies to side effects not listed in this leaflet. You can also report side effects directly to the Federal Institute for Drugs and Medical Devices, Dept. Pharmacovigilance, Kurt-Georg-Kiesinger-Allee 3, D-53175 Bonn, website: By reporting side effects you can help provide more information on the safety of this medicine.

5 How should Neurobion® N forte be stored?

Store drug out of reach of children.

The expiry date of this pack is printed on the side flap of the folding box and on the blister. Do not use this pack after the specified date!

Storage conditions:

Do not store above 25 ° C.


What Neurobion® N forte contains:

The active ingredients are: 1 coated tablet Neurobion® N forte contains N, N '- [disulfanediylbis (5-hydroxypent-2-en2-yl)] bis [N- (4-amino-2-methylpyrimidin-5-ylmethyl) formamide] (Thiamine disulfide) 100mg, pyridoxine hydrochloride 100mg.

The other ingredients are:

Magnesium stearate (Ph.Eur.), Hypromellose, sucrose (sucrose), talc, corn starch, lactose monohydrate, montan glycol wax, methyl cellulose, light magnesium oxide, basic butyl methacrylate copolymer (Ph.Eur.), Glycerol 85%, povidone (K 25) , Calcium carbonate, highly dispersed silicon dioxide, white clay, titanium dioxide (E 171)

What Neurobion® N forte looks like and contents of the pack:

Box of 20, 50 or 100 coated tablets

Pharmaceutic entrepreneur

Merck Self-Medication GmbH

Frankfurter Str. 250

64293 Darmstadt

Tel.-No .: 0 61 51/8 56–2260

Fax no .: 0 61 51/8 56–2203


Merck Kommanditgesellschaft auf Aktien + Co.,

Spittal plant,

A-9800 Spittal / Drau


7 Price comparison - Neurobion® N forte

Neurobion® N forte price comparison

For the purchase, we recommend the pharmacy price comparison There the prices of over 70 certified mail-order pharmacies are compared, which means that Neurobion® N forte can be ordered cheaply.

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On this page you will find instructions for use for medical products and medicines. The information comes from the product manufacturers themselves - we have only compiled it. Visiting this website cannot replace a doctor.